I hate ’em. Why doesn’t anybody ever tell you about it? It’s as simple as putting this in the manual:

“Due to this pedal’s unique circuitry, it is recommended that you place it before any pedals with buffered bypass” or “This pedal is designed to receive the signal directly from your guitar. To achieve the intended sound, it should be placed first in your signal chain.”

I tend to expect it with fuzz pedals, especially true vintage reissues like the Fender Blender and Muff overdrive, but there are even some distortion pedals that hate buffers. I spent the last month with the Fat Sandwich’s treble rolled nearly all the way back, just last week I took the TU-2 out of my chain because I was recording and realized that the Fat Sandwich just hates buffers. Ridiculous!